Dick Tibboel Selected Research

C-Reactive Protein

1/2018	Predicting CYP3A-mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure.
1/2016	Inflammation and Organ Failure Severely Affect Midazolam Clearance in Critically Ill Children.
1/2012	The effect of critical illness and inflammation on midazolam therapy in children.

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Dick Tibboel Research Topics

Disease

78	Pain (Aches) 01/2024 - 08/2002
48	Critical Illness (Critically Ill) 01/2021 - 09/2002
43	Congenital Diaphragmatic Hernias 01/2022 - 03/2003
20	Pulmonary Hypertension 01/2021 - 07/2004
13	Postoperative Pain 01/2022 - 08/2002
13	Body Weight (Weight, Body) 01/2022 - 01/2008
13	Respiratory Insufficiency (Respiratory Failure) 11/2021 - 11/2003
10	Hypoxia (Hypoxemia) 01/2021 - 09/2004
7	Acute Kidney Injury (Acute Renal Failure) 11/2021 - 07/2013
7	Sepsis (Septicemia) 11/2021 - 07/2002
6	Procedural Pain 01/2022 - 11/2003
6	Heart Arrest (Cardiac Arrest) 01/2021 - 10/2012
6	Hypothermia 08/2020 - 10/2012
6	Infections 04/2020 - 05/2010
5	Birth Weight (Birth Weights) 09/2023 - 05/2004
5	Delirium 01/2023 - 01/2017
5	Lung Diseases (Lung Disease) 01/2023 - 10/2009
5	Persistent Fetal Circulation Syndrome 01/2021 - 01/2013
5	Esophageal Atresia 10/2020 - 07/2007
5	Substance Withdrawal Syndrome (Withdrawal Symptoms) 12/2019 - 08/2007
5	Chronic Pain 01/2019 - 09/2009
5	Inflammation (Inflammations) 01/2018 - 01/2012
4	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2023 - 01/2007
4	Bronchopulmonary Dysplasia 01/2023 - 01/2016
4	Asphyxia (Suffocation) 01/2022 - 11/2003
4	Hypersensitivity (Allergy) 01/2022 - 01/2013
4	Hemorrhage 04/2018 - 09/2002
4	Necrotizing Enterocolitis 07/2012 - 11/2002
4	Meconium Aspiration Syndrome 03/2011 - 03/2003
3	Acute Pain 01/2022 - 03/2011
3	Neuralgia (Stump Neuralgia) 11/2020 - 01/2019
3	Hyperoxia 03/2017 - 12/2009
3	Septic Shock (Toxic Shock Syndrome) 03/2014 - 01/2011
3	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 03/2011 - 01/2008
2	Congenital Heart Defects (Congenital Heart Defect) 07/2023 - 01/2021
2	Heart Diseases (Heart Disease) 01/2023 - 07/2011
2	Reinjuries 01/2022 - 01/2021
2	Breakthrough Pain 12/2021 - 01/2019
2	Down Syndrome (Down's Syndrome) 01/2021 - 10/2016
2	Low Cardiac Output 01/2021 - 04/2016
2	Gastroesophageal Reflux (GERD) 10/2020 - 01/2017

Drug/Important Bio-Agent (IBA)

29	Analgesics (Analgesic Drugs)IBA 01/2024 - 09/2002
24	Morphine (MS Contin)FDA LinkGeneric 01/2024 - 08/2002
23	Opioid Analgesics (Opioids)IBA 09/2023 - 09/2002
17	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2024 - 07/2008
15	Hypnotics and Sedatives (Sedatives)IBA 01/2017 - 08/2007
13	Oxygen (Dioxygen)IBA 01/2023 - 11/2004
12	Biomarkers (Surrogate Marker)IBA 01/2023 - 11/2011
12	Proteins (Proteins, Gene)FDA Link 01/2023 - 11/2003
11	Midazolam (Versed)FDA LinkGeneric 01/2021 - 07/2008
9	Sildenafil Citrate (Viagra)FDA Link 01/2021 - 02/2010
8	Surface-Active Agents (Surfactants)IBA 04/2015 - 03/2003
7	Remifentanil (Ultiva)FDA Link 01/2019 - 11/2008
5	BenzodiazepinesIBA 10/2013 - 08/2007
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2011 - 09/2004
4	EnzymesIBA 01/2023 - 10/2005
4	CreatinineIBA 01/2022 - 12/2014
4	Gabapentin (Neurontin)FDA LinkGeneric 11/2020 - 01/2019
4	Fentanyl (Sublimaze)FDA LinkGeneric 01/2020 - 04/2005
4	Messenger RNA (mRNA)IBA 11/2019 - 11/2003
4	Indicators and Reagents (Reagents)IBA 03/2018 - 03/2008
4	nitrofenIBA 01/2015 - 11/2003
3	Hydrocortisone (Cortisol)FDA LinkGeneric 09/2023 - 01/2003
3	Phenobarbital (Luminal)FDA Link 01/2022 - 01/2018
3	Ibuprofen (Motrin)FDA LinkGeneric 11/2020 - 11/2015
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2019 - 11/2011
3	Propofol (Diprivan)FDA LinkGeneric 01/2019 - 03/2008
3	C-Reactive ProteinIBA 01/2018 - 01/2012
3	Brain Natriuretic Peptide (Natrecor)FDA Link 06/2016 - 01/2008
3	Vitamin A (Retinol)FDA LinkGeneric 01/2015 - 10/2010
3	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 09/2011 - 09/2004
3	RetinoidsIBA 10/2010 - 10/2005
3	Phosphatidylcholines (Phosphatidylcholine)IBA 10/2009 - 03/2003
3	GlucocorticoidsIBA 08/2008 - 12/2006
2	boldenone undecylenate (Equipoise)IBA 01/2024 - 02/2013
2	GlucuronidesIBA 09/2023 - 01/2009
2	Antipsychotic Agents (Antipsychotics)IBA 01/2023 - 01/2018
2	Anesthetics (Anesthetic Agents)IBA 01/2022 - 10/2019
2	Serotonin (5 Hydroxytryptamine)IBA 01/2022 - 07/2014
2	Vancomycin FDA LinkGeneric 11/2021 - 10/2019
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2021
2	Sufentanil (Sufenta)FDA LinkGeneric 01/2021 - 01/2016
2	Tramadol (K315)FDA LinkGeneric 11/2020 - 01/2019

Therapy/Procedure

47	Extracorporeal Membrane Oxygenation 09/2023 - 03/2003
23	Therapeutics 01/2023 - 11/2004
16	Analgesia 01/2023 - 09/2002
15	Critical Care (Surgical Intensive Care) 09/2023 - 01/2007
13	Artificial Respiration (Mechanical Ventilation) 09/2023 - 08/2002
9	Cardiopulmonary Bypass (Heart-Lung Bypass) 07/2023 - 01/2009
9	Pain Management 06/2018 - 11/2003
7	Length of Stay 01/2021 - 01/2006
6	Drug Therapy (Chemotherapy) 01/2019 - 06/2012
5	Induced Hypothermia 01/2022 - 10/2012
5	Enteral Nutrition (Feeding, Tube) 05/2015 - 11/2002
4	Anesthesia 01/2021 - 07/2008
4	Home Nursing (Nursing, Home) 01/2019 - 03/2009
4	Palliative Care (Palliative Therapy) 02/2018 - 10/2015
4	Parenteral Nutrition 03/2016 - 07/2002
3	Catheters 01/2017 - 03/2013
2	Cardiopulmonary Resuscitation (CPR) 01/2021 - 02/2013